Prostate carcinoma: immunohistochemical staining of Galectin-3. Note the staining in the neoplastic cells and some staining in the stroma. Galectin-3: clone 9C4

Galectin-3

galectin-3

Antigen Background

Galectin-3 is a member of the beta-galactosidase-binding lectin family. It is involved in several biological events including binding to the basement membrane glycoprotein laminin. Cell surface galectin-3 may be involved in homotypical cell adhesion and is downregulated in colon cancer as the disease progresses. This downregulation has also been examined in breast carcinoma with a similar correlation of expression reported. Downregulation of galectin-3 could be one of the many events that enable cancer cells to interact with laminin to facilitate invasion and metastasis and may indicate activation of the invasive phenotype in various tumor types.

Disclaimer
Galectin-3 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces GAL3-CEGAL3
    PA0238
    7ml Galectin-3 Bond RTU Primary
    9C4
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

PA0238
Hematopathology
9C4
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

PA0238

Resources

Resources

Antigen Background

Galectin-3 is a member of the beta-galactosidase-binding lectin family. It is involved in several biological events including binding to the basement membrane glycoprotein laminin. Cell surface galectin-3 may be involved in homotypical cell adhesion and is downregulated in colon cancer as the disease progresses. This downregulation has also been examined in breast carcinoma with a similar correlation of expression reported. Downregulation of galectin-3 could be one of the many events that enable cancer cells to interact with laminin to facilitate invasion and metastasis and may indicate activation of the invasive phenotype in various tumor types.

Disclaimer
Galectin-3 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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