Colon mucosa: immunohistochemical staining for Cytokeratin 8/18: clone 5D3

Cytokeratin (8/18)

cytokeratin-818

Antigen Background

In normal tissues, cytokeratins 8 and 18 are reported to be expressed in all simple and glandular epithelium and in neoplastic tissues, they have been reported to be expressed in adenocarcinomas and most squamous cell carcinomas. These cytokeratins are absent from keratinizing squamous carcinomas.

Product Specific Information

Clone 5D3 reacts with human cytokeratin intermediate filament proteins of 52.5 kD and 45 kD, identified as cytokeratins 8 and 18, respectively. Clone 5D3 shares similar specificities to clone CAM5.2 (Angus B et al. Journal of Pathology. 153: 377-384 (1987)).

Disclaimer
Cytokeratin (8/18) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces 5D3-R-7-CE5D3-R-75D35D3-L5D3-CE
    5D3-L-CE
    1ml NCL-L-5D3
    5D3
    Liquid Concentrate
    P (ENZYME)
  • PA0067
    7ml CK8/18 Bond RTU Primary
    5D3
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

5D3-L-CE
Tumor Differentiation
5D3
Liquid Concentrate
No
P (ENZYME)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0067
Tumor Differentiation
5D3
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

5D3-L-CE
PA0067

Resources

Resources

Antigen Background

In normal tissues, cytokeratins 8 and 18 are reported to be expressed in all simple and glandular epithelium and in neoplastic tissues, they have been reported to be expressed in adenocarcinomas and most squamous cell carcinomas. These cytokeratins are absent from keratinizing squamous carcinomas.

Product Specific Information

Clone 5D3 reacts with human cytokeratin intermediate filament proteins of 52.5 kD and 45 kD, identified as cytokeratins 8 and 18, respectively. Clone 5D3 shares similar specificities to clone CAM5.2 (Angus B et al. Journal of Pathology. 153: 377-384 (1987)).

Disclaimer
Cytokeratin (8/18) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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