Cytokeratins 5, 6 and 18 are reported to be expressed in a broad range of human epithelial tissues, from simple glandular epithelia to stratified squamous epithelia. These include epithelial cells that are ectodermal, mesodermal, or endodermal in origin. These cytokeratins have been reported to be expressed in tumor cells of epithelial origin and less commonly of mesothelial origin. Non-epithelial tumors such as lymphomas do not express these cytokeratins.
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The recognition of cytokeratin 18 on formalin fixed paraffin embedded sections using clone LP34 may be variable.
Cytokeratin (5/6/18) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.