In normal tissues cytokeratin 17 is reported to be expressed in basal cells of complex epithelia, for example, basal cells of pseudostratified epithelium in the trachea, larynx, bronchi, myoepithelial cells in salivary glands and sweat glands. In neoplastic tissue, cytokeratin 17 is reported to be expressed in squamous cell carcinomas of the lung, cervix and oral cavity.
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CK17 reacts with the human cytokeratin intermediate filament protein (46 kD) identified as cytokeratin 17.
Cytokeratin 17 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.