Human tonsil: immunohistochemical staining for CD68. Note the germinal centre macrophages show a strong cytoplasmic staining reaction, while the interfollicular macrophages show correct weak to moderate staining reaction. CD68: clone 514H12

CD68

cd68

Antigen Background

The CD68 molecule is a 110 kD intracellular glycoprotein primarily reported to be associated with cytoplasmic granules and to a lesser extent the membranes of macrophages. Markers to CD68 antigen are the most frequently used for the identification of macrophages in immunohistochemistry; however, CD68 is also found in monocytes, neutrophils, basophils and large lymphocytes. The function of the CD68 molecule is not certain but these lysosomal membrane proteins are major components and may protect the membranes from attack by acid hydrolases. It is unclear if the surface-associated CD68 protein is functionally significant or due to leakage from the lysosomes. CD68 protein expression has been demonstrated in stimulated T cells and NK cells and non-hematopoietic tissues such as liver and renal tubules.

Disclaimer

CD68 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces CD68-L-CE-SCD68-KP1CD68-SCD68-R-7CD68-L-ACD68CD68-L-S
    CD68-L-CE
    1ml NCL-L-CD68
    514H12
    Liquid Concentrate
    P (HIER)
  • PA0273
    7ml CD68 Bond RTU Primary
    514H12
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

CD68-L-CE
Hematopathology
514H12
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0273
Hematopathology
514H12
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

CD68-L-CE
PA0273

Resources

Resources

Antigen Background

The CD68 molecule is a 110 kD intracellular glycoprotein primarily reported to be associated with cytoplasmic granules and to a lesser extent the membranes of macrophages. Markers to CD68 antigen are the most frequently used for the identification of macrophages in immunohistochemistry; however, CD68 is also found in monocytes, neutrophils, basophils and large lymphocytes. The function of the CD68 molecule is not certain but these lysosomal membrane proteins are major components and may protect the membranes from attack by acid hydrolases. It is unclear if the surface-associated CD68 protein is functionally significant or due to leakage from the lysosomes. CD68 protein expression has been demonstrated in stimulated T cells and NK cells and non-hematopoietic tissues such as liver and renal tubules.

Disclaimer

CD68 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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