Human lymphoma: immunohistochemistry staining for CD31. Note the membrane staining of endothelial cells. CD31: Clone JC70A

CD31 (PECAM-1)

cd31-pecam-1

Antigen Background

CD31 antigen (PECAM-1) is a single chain transmembrane glycoprotein with a molecular weight of 130 to 140 kD. The CD31 molecule is expressed on the surface of platelets, monocytes, granulocytes, B cells and at the endothelial intracellular junction. The molecule has an extracellular domain that contains six Ig-like homology units of C2 subclass, typical of cell to cell adhesion molecules. This domain mediates endothelial cell to cell adhesion, plays a role in endothelial contact and may serve to stabilize the endothelial cell monolayer. The CD31 molecule also has a cytoplasmic domain with potential sites for phosphorylation after cellular activation. The properties of CD31 antigen suggest that it is involved in interactive events during angiogenesis, thrombosis and wound healing. Angiogenesis is essential for tumor growth and metastases.

Disclaimer

CD31 (PECAM-1) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains. 

  • CD31-607-L-CE
    1ml NCL-L-CD31-607
    JC70A
    Liquid Concentrate
    P (HIER)
  • PA0414
    7ml CD31 (JC70A) Bond RTU Primary
    JC70A
    BOND RTU
    P (HIER)
  • PA0250
    7ml CD31 Bond RTU Primary
    1A10
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

CD31-607-L-CE
Soft Tissue Pathology
JC70A
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0414
Soft Tissue Pathology
JC70A
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml
PA0250
Soft Tissue Pathology
1A10
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

CD31-607-L-CE
PA0414
PA0250

Resources

Resources

Antigen Background

CD31 antigen (PECAM-1) is a single chain transmembrane glycoprotein with a molecular weight of 130 to 140 kD. The CD31 molecule is expressed on the surface of platelets, monocytes, granulocytes, B cells and at the endothelial intracellular junction. The molecule has an extracellular domain that contains six Ig-like homology units of C2 subclass, typical of cell to cell adhesion molecules. This domain mediates endothelial cell to cell adhesion, plays a role in endothelial contact and may serve to stabilize the endothelial cell monolayer. The CD31 molecule also has a cytoplasmic domain with potential sites for phosphorylation after cellular activation. The properties of CD31 antigen suggest that it is involved in interactive events during angiogenesis, thrombosis and wound healing. Angiogenesis is essential for tumor growth and metastases.

Disclaimer

CD31 (PECAM-1) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains. 

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