Human tonsil: immunohistochemical staining for CD22. Note the mantle zone is staining stronger than the germinal centre. CD22: clone FPC1

CD22

cd22

Antigen Background

The CD22 antigen (BL-CAM) is a type 1 integral membrane glycoprotein with a molecular weight of 130 to 140 kD. It is a heterodimer of two independently expressed glycoprotein chains present both on the membrane and in the cytoplasm of B lymphocytes. Expression of the CD22 antigen is reported to appear early in B cell lymphocyte differentiation at approximately the same stage as that of the CD19 antigen expression. Surface antigen expression is variable and may be lost upon differentiation. CD22 antigen is also reported to be weakly expressed on myeloid leukemias and non-T cell acute lymphoblastic leukemias and is strongly expressed on hairy cell leukemias. It is absent on peripheral blood T cells, T cell leukemias, granulocytes and monocytes.

Disclaimer

CD22 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces CD22-2-SCD22-2
    PA0249
    7ml CD22 Bond RTU Primary
    FPC1
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

PA0249
Hematopathology
FPC1
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

PA0249

Resources

Resources

Antigen Background

The CD22 antigen (BL-CAM) is a type 1 integral membrane glycoprotein with a molecular weight of 130 to 140 kD. It is a heterodimer of two independently expressed glycoprotein chains present both on the membrane and in the cytoplasm of B lymphocytes. Expression of the CD22 antigen is reported to appear early in B cell lymphocyte differentiation at approximately the same stage as that of the CD19 antigen expression. Surface antigen expression is variable and may be lost upon differentiation. CD22 antigen is also reported to be weakly expressed on myeloid leukemias and non-T cell acute lymphoblastic leukemias and is strongly expressed on hairy cell leukemias. It is absent on peripheral blood T cells, T cell leukemias, granulocytes and monocytes.

Disclaimer

CD22 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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