Human malignant melanoma: immunohistochemical staining for CD146. Note membrane staining of metastatic melanocytes and endothelial cells. CD146: clone N1238

CD146 (MCAM)


Antigen Background

CD146 protein is also known as the melanoma metastasis-associated surface molecule, MUC18, A32 antigen, S-Endo-1 and the melanoma cell adhesion molecule, MCAM or Mel-CAM. Originally, the CD146 molecule was defined as a marker of tumor progression and metastasis formation in human melanoma. More recently, it has been reported to be expressed on endothelial cells, smooth muscle and cerebellar cortex. Structurally, CD146 is an integral membrane glycoprotein of 113 kD with the characteristic V-V-C2-C2-C2 immunoglobulin-like domain structure. It shares considerable homology with chicken neural adhesion molecule, chicken gicerin, goldfish neurolin and is also closely related to the human blood group glycoprotein, lutheran. Although CD146 molecule functions as a cell adhesion molecule it interacts with an as yet uncharacterized ligand. CD146 can be induced on all T cells via PHA, recall antigen, superantigen and T cell receptor/CD3 stimulation. Furthermore reports suggest that the CD146 molecule is involved in the extravasation and homing of activated T cells. CD146 protein can promote tumor progression in human melanoma, possibly through enhanced interaction between melanoma cells and endothelial cells. In contrast, CD146 protein may act as a tumor suppressor in breast carcinoma with expression frequently lost in some cases.


CD146 (MCAM) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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