Human high walled venule endothelium and plasmacytoid dendritic cells: immunohistochemical staining for CD123: clone BR4MS

CD123

cd123

Antigen Background

The CD123 antigen is also known as the alpha subunit of the human interleukin-3 receptor. It is a type I transmembrane glycoprotein and is a member of the cytokine receptor superfamily. CD123 forms a heterodimer with CD131 (the beta subunit of the interleukin-3 receptor) to form the interleukin-3 receptor, where the cytokine specificity is provided by the alpha subunit and the signal transduction function is provided by the beta subunit. The interleukin-3 receptor is reported to be expressed on monocytes, neutrophils, basophils, eosinophils, megakaryocytes, erythroid precursors, mast cells, macrophages and a subpopulation of B cells, where it mediates proliferation and differentiation of these cells. Outside the hematopoietic system CD123 is reported to be expressed in Leydig cells of the testis, some endothelial cells, and cells of the placenta and brain.

Disclaimer

CD123 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces CD123-L-SCD123-L-CE-S
    CD123-L-CE
    1ml NCL-L-CD123
    BR4MS
    Liquid Concentrate
    P (HIER)

Product Specifications

Product Specifications

CD123-L-CE
Hematopathology
BR4MS
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml

Documents

Documents

CD123-L-CE

Resources

Resources

Antigen Background

The CD123 antigen is also known as the alpha subunit of the human interleukin-3 receptor. It is a type I transmembrane glycoprotein and is a member of the cytokine receptor superfamily. CD123 forms a heterodimer with CD131 (the beta subunit of the interleukin-3 receptor) to form the interleukin-3 receptor, where the cytokine specificity is provided by the alpha subunit and the signal transduction function is provided by the beta subunit. The interleukin-3 receptor is reported to be expressed on monocytes, neutrophils, basophils, eosinophils, megakaryocytes, erythroid precursors, mast cells, macrophages and a subpopulation of B cells, where it mediates proliferation and differentiation of these cells. Outside the hematopoietic system CD123 is reported to be expressed in Leydig cells of the testis, some endothelial cells, and cells of the placenta and brain.

Disclaimer

CD123 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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