Human medullary thyroid carcinoma: immunohistochemical staining for Calcitonin. Calcitonin: clone CL1948

Calcitonin

calcitonin

Antigen Background

Calcitonin (CT) is a 32 amino acid peptide synthesized by the parafollicular C cells of the thyroid. It acts through its receptors to inhibit osteoclast mediated bone resorption, decrease calcium resorption by the kidney and decrease calcium absorption by the intestines. The action of calcitonin is therefore to cause a reduction in serum calcium, an effect opposite to that of parathyroid hormone. The calcitonin gene transcript also encodes the calcitonin gene-related peptide (CGRP), which is thought to be a potent vasodilator. The tissue specificity of the transcript produced depends on alternative splicing of the CT/CGRP gene transcript. In the parafollicular cells of the thyroid 95% of the CT/CGRP is processed and translated to produce CT, however, in neuronal cells 99% of the CT/CGRP RNA is translated into CGRP. The C cells of the thyroid give rise to an endocrine tumor, medullary thyroid carcinoma (MTC), which occurs in a sporadic (75% of cases) and hereditary form (25% of cases). Familial MTC is associated with C cell hyperplasia (CCH), whereas sporadic MTC is thought not to be. However, in the general population CCH is present in 20-30% of thyroid glands, either with normal histology, thyroiditis or follicular tumors.

Disclaimer

Calcitonin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains. 

  • This item replaces CALCITONIN-L-CE-SCALCITONIN-LCALCITONIN-L-S
    CALCITONIN-L-CE
    1ml NCL-L-Calcitonin
    CL1948
    Liquid Concentrate
    P (ENZYME)
  • PA0406
    7ml Calcitonin Bond RTU Prim
    POLYCLONAL
    BOND RTU
    P (ENZYME)

Product Specifications

Product Specifications

CALCITONIN-L-CE
Head, Neck and Endocrine
CL1948
Liquid Concentrate
No
P (ENZYME)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0406
Head, Neck and Endocrine
POLYCLONAL
BOND RTU
No
P (ENZYME)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

CALCITONIN-L-CE
PA0406

Resources

Resources

Antigen Background

Calcitonin (CT) is a 32 amino acid peptide synthesized by the parafollicular C cells of the thyroid. It acts through its receptors to inhibit osteoclast mediated bone resorption, decrease calcium resorption by the kidney and decrease calcium absorption by the intestines. The action of calcitonin is therefore to cause a reduction in serum calcium, an effect opposite to that of parathyroid hormone. The calcitonin gene transcript also encodes the calcitonin gene-related peptide (CGRP), which is thought to be a potent vasodilator. The tissue specificity of the transcript produced depends on alternative splicing of the CT/CGRP gene transcript. In the parafollicular cells of the thyroid 95% of the CT/CGRP is processed and translated to produce CT, however, in neuronal cells 99% of the CT/CGRP RNA is translated into CGRP. The C cells of the thyroid give rise to an endocrine tumor, medullary thyroid carcinoma (MTC), which occurs in a sporadic (75% of cases) and hereditary form (25% of cases). Familial MTC is associated with C cell hyperplasia (CCH), whereas sporadic MTC is thought not to be. However, in the general population CCH is present in 20-30% of thyroid glands, either with normal histology, thyroiditis or follicular tumors.

Disclaimer

Calcitonin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains. 

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