Human colon polyp: immunohistochemical staining for Beta-Catenin. Note the abnormal translocation of the protein to the nucleus. Beta-Catenin: clone 17C2

Beta-Catenin

beta-catenin

Antigen Background

The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell-to-cell contact, which in itself is critical for adhesion, signal transmission and for anchoring the actin cytoskeleton. Beta-catenin's role is as a transcription effector of the wnt-signaling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway activation. This aberrant expression is observed in human tumorigenesis, and especially in colorectal cancer.

Disclaimer

Beta-Catenin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces B-CAT-L-UB-CAT-U
    B-CAT-L-CE
    1ml NCL-L-B-CAT
    17C2
    Liquid Concentrate
    P (HIER)
  • This item replaces B-CATB-CAT-S
    PA0083
    7ml Beta-Catenin Bond RTU Primary
    17C2
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

B-CAT-L-CE
Soft Tissue Pathology
17C2
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0083
Soft Tissue Pathology
17C2
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

B-CAT-L-CE
PA0083

Resources

Resources

Antigen Background

The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell-to-cell contact, which in itself is critical for adhesion, signal transmission and for anchoring the actin cytoskeleton. Beta-catenin's role is as a transcription effector of the wnt-signaling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway activation. This aberrant expression is observed in human tumorigenesis, and especially in colorectal cancer.

Disclaimer

Beta-Catenin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Recently Viewed

View All