Human follicular lymphoma: neoplastic cells show a moderate, predominantly cytoplasmic staining reaction. Bcl-2: clone bcl-2/100/D5

bcl-2 Oncoprotein

bcl-2-oncoprotein

Antigen Background

Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor of apoptosis. For this reason, bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway.

In 90% of follicular lymphomas a translocation occurs which juxtaposes the bcl-2 gene at 18q21, to an immunoglobulin gene. This t(14;18) translocation can deregulate gene expression and bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas.

Disclaimer

Bcl-2 Oncoprotein is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • BCL-2-L-CE
    1ml NCL-L-bcl-2
    BCL-2/100/D5
    Liquid Concentrate
    P (HIER)
  • PA0117
    7ml Bcl-2 Bond RTU Primary
    BCL-2/100/D5
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

BCL-2-L-CE
Hematopathology
BCL-2/100/D5
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0117
Hematopathology
BCL-2/100/D5
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

BCL-2-L-CE
PA0117

Resources

Resources

Antigen Background

Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor of apoptosis. For this reason, bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway.

In 90% of follicular lymphomas a translocation occurs which juxtaposes the bcl-2 gene at 18q21, to an immunoglobulin gene. This t(14;18) translocation can deregulate gene expression and bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas.

Disclaimer

Bcl-2 Oncoprotein is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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