Human follicular lymphoma: neoplastic cells show a moderate, predominantly cytoplasmic staining reaction. Bcl-2: clone Bcl-2/100/D5

Bcl-2 Oncoprotein

Antigen Background

Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor of apoptosis. For this reason, Bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway.

In 90% of follicular lymphomas a translocation occurs which juxtaposes the Bcl-2 gene at 18q21, to an immunoglobulin gene. This t(14;18) translocation can deregulate gene expression and Bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas.

Disclaimer

Bcl-2 Oncoprotein is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

$ 434.61 
Please be advised we have recently updated our product codes for many Advanced Staining Reagents. We ask that you please update your records at this time.

Please see here for more information

Products

Products

BCL-2-L-CE
bcl-2 Oncoprotein, Liquid Concentrate (1ml)
Limited Stock (More Details)
Ships via Overnight
Online-only price (details)
$ 434.61
PA0117
7ml Bcl-2 Bond RTU Primary
Limited Stock (More Details)
Ships via Overnight
LOG IN to check your price,
or REQUEST a bulk quote.

Downloads

Downloads

BCL-2-L-CE

PA0117

Recently Viewed