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Deletion of TP53 (previously known as p53) and ATM are both indicating poor prognosis in CLL. Alterations of the TP53 (17p13) gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Deletions of TP53 are frequent in CLL and MM, usually associated with unfavorable prognosis. Deletions of the long arm of chromosome 11 (11q) are one of the most frequent structural chromosome aberrations in various types of lymphoproliferative disorders. A critical genomic region located in bands 11q22.3-q23.1 has been identified and contains among other genes the ATM (ataxia telangiectasia mutated) gene.
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