IVD IGH Break

Multiple myeloma is characterized by complex rearrangements involving the IgH gene, particularly at the constant locus. The IgH rearrangement provides a useful marker of clonality in B-cell malignancies and amplification of this rearrangement is the method of choice to monitor the residual tumor cells in multiple myeloma. The IGH (14q32) break probe is optimized to detect translocations involving the IGH gene region at 14q32 in a dual-color, split assay.

References:
Taniwaki et al, 1994, Blood, 83; 2962-1969.
Gozetti et al, 2002, Cancer Research, 62; 5523-5527.