RUO - MAFB (20q12) / IGH (14q32)

The immunoglobulin heavy chain (IGH) gene at 14q32 is an important cause of genetic deregulation in MM. Among the known fusion partners for the IGH (previously known as IGH@) gene, reciprocal translocation with the MAFB gene at 20q12 is relatively rare in MM (~2% occurrence). However, the MAFB / IGH t(14;20) translocation is associated with poor prognosis in multiple myeloma patients. The MAFB / IGH t(14;20) Fusion FISH probe is optimized to detect the reciprocal translocation t(14;20) in a dual-color, dual-fusion assay on metaphase/interphase spreads and bone marrow cells.

References:

Boersma-Vreugdenhil GR et al, 2004, Br J Haematol, 126; 355-363.

Bergsagel PL et al, 2005, JCO, 23; 6333-6338.