Human skeletal muscle: immunohistochemical staining for Utrophin. In control muscle the antibody labels blood vessels and neuromuscular junctions (A). Utrophin is expressed at the sarcolemma in individuals with mutations in the DMD gene (B). Utrophin: clone DRP3/20C5

Utrophin

utrophin

Antigen Background

The utrophin gene is located on chromosome 6. The protein is a homologue of dystrophin and is known as dystrophin-related protein. In normal muscle, utrophin is restricted to neuromuscular junctions; however, in dystrophin-deficient muscle, utrophin expression may be upregulated and labeling appears around the periphery of most fibers. lmmunohistochemical staining with DRP2 labels vessels and neuromuscular junctions and the upregulated form of utrophin, located around fiber membranes.

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Utrophin is recommended for the detection of specific antigens of interest in normal and abnormal tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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