PDGFRB (5q32) Break probe hybridized to a normal metaphase (2RG).

IVD PDGFRB Break

ivd-pdgfrb-break
PDGFRB activation has been observed in patients with chronic myelomonocytic leukemia/atypical chronic myeloid leukemia and has been associated with over 50 translocation partners, the best known is the ETV6 gene on 12p13, causing a t(5;12) translocation. Cytogenetic responses are achieved with imatinib in patients with PDGFRB fusion positive, BCR/ABL1 negative CMPDs. The PDGFRB (5q32) Break FISH probe is optimized to detect translocations involving the PDGFRB region at 5q32 in a dual-color, split assay.

References:
Wlodarska et al, 1997, Blood, 89; 1716-1722.
Wilkinson et al, 2003, Blood, 102; 4287-419.

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KBI-10004
PDGFRB (5q32) Break
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Hematopathology
In Vitro Diagnostic Use
10 test
Dual Color > Red, Green
Cells
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent

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