FISH result of the EWSR1/NFATC2 t(20;22) DC, S-Fusion probe.
Ewing's sarcoma is the second most frequent primary bone cancer. In most cases a translocation involving the EWSR1 gene at 22q12 and the FLI1 gene at 11q24 is observed. Several other translocation partners of the ETS gene family can also be involved. The first non-ETS family translocation partner described is the NFATC2 gene (nuclear factor of activated T-cells, cyto-plasmic, calcineurin-dependent 2) at 20q13. The EWSR1/NFATC2 t(20;22) Dual-Color Single-Fusion probe is optimized to detect the t(20;22)(q13;q12) involving the NFATC2 (20q13) and EWSR1 (22q12) gene regions in a dual-color, single fusion assay on paraffin embedded tissue sections.
References: Szuhai et al, 2009, Clin Cancer Res, 15; 2259-2268. Zucman-Rossi et al, 1998, PNAS, 95; 11786-11791. Bernstein et al, 2006, Oncologist, 11; 503-519.