Hybridization of MYC/IGH fusion probe to a metaphase spread showing normal pattern (2R2G).
IVD MYC/IGH t(8;14) Fusion
The translocation t(8;14)(q24;q32) is the characteristic chromosomal aberration of Burkitt's-type of lymphomas. This translocation fuses the MYC gene at 8q24 next to the IGH locus at 14q32, resulting in overexpression of the transcription factor MYC. Detection of the t(8;14) is aimed to help in the diagnostic process of patients with high-grade B-cell lymphomas because treatment strategies differ between Burkitt and other high-grade lymphomas. The MYC/IGH t(8;14)(q24;q32) specific FISH probe is optimized to detect the reciprocal translocation t(8;14) in a dual-color, dual-fusion assay.
References: Veronese et al, 1995, Blood, 85;2132-2138. Siebert et al, 1998, Blood, 91; 984-990.