DLEU1 (13q14) / 13qter probe hybridized to patient material showing a 13q14 deletion (1R2G). Image kindly provided by Dr. Dastugue, Toulouse.
Deletions of chromosome 13q14 have been reported not only in CLL but in a variety of human tumors, including other types of lymphoid and myeloid tumors, as well as prostate, head and neck, and non-small cell lung cancers. The deletion of 13q may be limited to a single locus (13q14), or accompanied with the loss of a larger interstitial region of the long arm of chromosome 13. A minimal critical region of 400 kb has been described containing the DLEU1, DLEU2 and RFP2 genes. The DLEU1 (13q14) specific FISH probe is optimized to detect copy numbers of the DLEU1 (previously known as DLEU) gene region at 13q14. The 13qter (13q34) region is included to facilitate chromosome identification.
References: Wolf et al, 2001, Hum Mol Genet, 10; 1275-1285. Corcoran et al, 1998, Blood, 91; 1382-1390.