Human skin: immunohistochemical staining for Mast Cell Tryptase. Note cytoplasmic staining of mast cells. Mast Cell Tryptase: clone 10D11

Mast Cell Tryptase

mast-cell-tryptase

Antigen Background

Mast cells contain a number of preformed chemical mediators such as histamine, chymase, carboxypeptidase and proteolytic tryptase. A substantial quantity of tryptase is reported to be found in mast cells of skin and lung and suggests this enzyme plays a major role in mast cell mediated events. In vitro studies indicate tryptase can cleave C3 to form C3a anaphylatoxin, inactivate fibrinogen as a coaguable substrate for thrombin and activate latent collagenase. Models of allergenic disease in the skin, nose and lung have each indicated elevated tryptase levels. Human mast cell tryptase has been reported to be implicated as a mediator of inflammation. Mast cell degranulation in the gut causes mucus secretion, mucosal edema, increased gut permeability and may be responsible for some of the symptoms and signs of inflammatory bowel disease.

Disclaimer

Mast Cell Tryptase is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • PA0019
    Mast Cell Tryptase
    10D11
    BOND RTU
    P

製品仕様書

製品仕様書

PA0019
Hematopathology
10D11
BOND RTU
No
P
Mono
Mouse
In Vitro Diagnostic Use
7ml

カタログ・取扱説明書など

カタログ・取扱説明書など

関連資料

関連資料

Antigen Background

Mast cells contain a number of preformed chemical mediators such as histamine, chymase, carboxypeptidase and proteolytic tryptase. A substantial quantity of tryptase is reported to be found in mast cells of skin and lung and suggests this enzyme plays a major role in mast cell mediated events. In vitro studies indicate tryptase can cleave C3 to form C3a anaphylatoxin, inactivate fibrinogen as a coaguable substrate for thrombin and activate latent collagenase. Models of allergenic disease in the skin, nose and lung have each indicated elevated tryptase levels. Human mast cell tryptase has been reported to be implicated as a mediator of inflammation. Mast cell degranulation in the gut causes mucus secretion, mucosal edema, increased gut permeability and may be responsible for some of the symptoms and signs of inflammatory bowel disease.

Disclaimer

Mast Cell Tryptase is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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