Breast carcinoma: immunohistochemical staining of Progesterone Receptor. Note the nuclear staining in a proportion of tumor cells. Progesterone Receptor: clone 16

Progesterone Receptor

progesterone-receptor
Antigen Background
The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor (ER)-inducible promoters within a single copy PR gene.

The PRA form is a truncated version of the PRB form, lacking the first 164 N-terminal amino acids. In humans, PRA acts as a transdominant repressor of the transcriptional activity of PRB, glucocorticoid receptor, ER, androgen receptor and mineralocorticoid receptor.PRB functions mainly as a transcriptional activator. PRB is expressed strongly in endometrial glandular and stromal nuclei in the proliferative phase of the menstrual cycle and weakly during the secretory phase and early pregnancy.

Product Specific Information
Clone 16 is specific for a region of the N-terminus of the A form of PR. The precise epitope has not been mapped but it reacts with both A and B forms of PR by Western blot but only with the A form by immunohistochemistry. This suggests that the epitope is inaccessible in the native folded B form of the protein.

Disclaimer
Progesterone Receptor is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  •  This item has been replaced by PGR-312-L-CE
    PGR-312-L-CE-S
    Voir Disponibilité
    0.1ml NCL-L-PGR-312
    16
  • This item replaces PGR-312-R-7PGR-312PGR-312/2PGR-312-R-7-CEPGR-312-CEPGR-312-LPGR-312/2-LPGR-312-L-SPGR-R-7-CEPGRPPGR-312-L-CE-S
    PGR-312-L-CE
    Voir Disponibilité
    1ml NCL-L-PGR-312
    16
    Liquid Concentrate
    P (HIER)
  • This item replaces PGR-312-R-7-FPGR-312-O-F
    PGR-312-L-F
    Voir Disponibilité
    1ml NCL-L-PGR-312 - FDA
    16
    Liquid Concentrate
    P (HIER)
  • PGR-312/2-L-CE
    Voir Disponibilité
    2ml NCL-L-PGR-312/2
    16
    Liquid Concentrate
    P (HIER)
  • PGR-312-L-CN
    Voir Disponibilité
    NCL-L-PGR-312
    16
    Liquid Concentrate
    P (HIER)
    SDS
  • PA0312
    Voir Disponibilité
    7ml PR Bond RTU Primary
    16
    BOND RTU
    P (HIER)

Caractéristiques Produits

Caractéristiques Produits

PGR-312-L-CE-S
16
In Vitro Diagnostic Use
PGR-312-L-CE
Breast Pathology
16
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PGR-312-L-F
Breast Pathology
16
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PGR-312/2-L-CE
Breast Pathology
16
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
2ml
PGR-312-L-CN
16
Liquid Concentrate
P (HIER)
In Vitro Diagnostic Use
PA0312
Breast Pathology
16
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

Ressources

Ressources

Antigen Background
The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor (ER)-inducible promoters within a single copy PR gene.

The PRA form is a truncated version of the PRB form, lacking the first 164 N-terminal amino acids. In humans, PRA acts as a transdominant repressor of the transcriptional activity of PRB, glucocorticoid receptor, ER, androgen receptor and mineralocorticoid receptor.PRB functions mainly as a transcriptional activator. PRB is expressed strongly in endometrial glandular and stromal nuclei in the proliferative phase of the menstrual cycle and weakly during the secretory phase and early pregnancy.

Product Specific Information
Clone 16 is specific for a region of the N-terminus of the A form of PR. The precise epitope has not been mapped but it reacts with both A and B forms of PR by Western blot but only with the A form by immunohistochemistry. This suggests that the epitope is inaccessible in the native folded B form of the protein.

Disclaimer
Progesterone Receptor is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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