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The Topoisomerase2A (TOP2A) enzyme, which is vital for the cell because of its role in cell replication and repair, catalyzes the relaxation of supercoiled DNA molecules to create a reversible double-strand DNA break. This enzyme is also the target of a number of cytotoxic agents, namely TOP2A inhibitors (anthracyclines, etoposide, teniposide). The TOP2A (17q21) / SE 17 FISH probe is optimized to detect amplifications (copy numbers) or deletions of the TOP2A gene region at the 17q21. The chromosome 17 satellite enumeration probe (SE 17) at D17Z1 is included to facilitate chromosome identification.
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