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The immunoglobulin heavy chain (IGH) gene at 14q32 is an important cause of genetic deregulation in MM. Among the known fusion partners for the IGH (previously known as IGH@) gene, reciprocal translocation with the MAFB gene at 20q12 is relatively rare in MM (~2% occurrence). However, the MAFB / IGH t(14;20) translocation is associated with poor prognosis in multiple myeloma patients. The MAFB / IGH t(14;20) Fusion FISH probe is optimized to detect the reciprocal translocation t(14;20) in a dual-color, dual-fusion assay on metaphase/interphase spreads and bone marrow cells.
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