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Chromosomal rearrangements involving the mixed lineage leukemia (MLL) gene at 11q23 are frequently observed in adult and childhood acute leukemia and are, in general, associated with poor prognosis. However, children with Acute Myeloid Leukemia (AML) carrying the t(9;11) KMT2A / MLLT3 (aka AF9) translocation have been described to be more sensitive to chemotherapy than patients with other 11q23 rearrangements. The KMT2A / MLLT3 Fusion FISH probe is optimized to detect translocations involving the KMT2A (previously known as MLL) and MLLT3 gene regions at 11q23 and 9p21 in a dual-color fusion assay on metaphase/interphase spreads, blood smears and bone marrow cells.
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