MYEOV / IGH t(11;14) Fusion probe hybridized to MM patient material showing t(11;14) translocation (2RG1R1G). Image kindly provided by Prof. Jauch, Heidelberg.

IVD MYEOV/IGH

ivd-myeov-igh
The most common chromosomal translocation in multiple myeloma (MM) is t(11;14), resulting in up-regulation of cyclin D1. In MM the breakpoints are scattered within a 360-kb region between CCND1 and MYEOV. This breakpoint is more proximal than the t(11;14) breakpoints observed in mantle cell lymphoma or other leukemias. Patients with MM who have t(11;14)(q13;q32) seem to have an aggressive clinical course. The MYEOV/IGH t(11;14)(q13;q32) Fusion specific FISH probe is optimized to detect the reciprocal translocation t(11;14) in a dual-color, dual-fusion assay.

References:
Janssen et al., 2000, Blood, 95; 2691-2698.
Fonseca et al, 2002, Blood, 99; 3735-3741.

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KBI-10605
ON MYEOV/IGH t(11;14) Fusion
Country availability

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Hematopathology
In Vitro Diagnostic Use
10 test
Dual Color > Red, Green
Cells
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent

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