KMT2A / MLLT1 t(11;19) Fusion probe hybridized to patient material showing t(11;19) translocation (2RG1R1G).

IVD KMT2A/MLLT1

ivd-kmt2a-mllt1
One of the relatively frequently observed translocations (around 10 %) in AML and ALL involves the genes KMT2A (previously known as MLL) and MLLT1 (aka ENL) at 11q23 and 19p13. The KMT2A/MLLT1 translocation results in the generation of fusion protein that retains the MLL N-terminus, including both an A-T hook domain and a region similar to mammalian DNA methyltransferase. There are several breakpoints within the MLLT1 gene described, without clear differences in clinicohematologic features. The KMT2A/MLLT1 Fusion probe is optimized to detect translocations involving the KMT2A and MLLT1 gene regions at 11q23 and 19p13 in a dual-color, fusion assay on metaphase/interphase spreads, blood smears and bone marrow cells in a dual-color, fusion assay.

References:
Mitterbauer-Hohdanner G et al, 2004, Eur J Clin Invest, 34; 12-24.
Meyer C et al, 2009, Leukemia, 23; 1490-1499.
Fu JF et al, 2007, Am J Clin Pathol, 127; 24-30.

Products

Products

KBI-10307
ON MLL/MLLT1 t(11;19) Fusion
Country availability

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Hematopathology
In Vitro Diagnostic Use
10 test
Dual Color > Red, Green
Cells
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent

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