Hybridization of DEK/NUP214 Fusion Probe to a positive cell line showing a fusion due to t(6;9).

IVD DEK/NUP214

ivd-dek-nup214
The chromosomal translocation t(6;9) (p22;q34) is associated with a specific subtype of acute myeloid leukemia (AML) and constitutes 0.5% to 4% of all AML cases. The translocation results in a fusion between the DEK oncogene (6p22) and the nucleoporin 214 kDa (NUP214 at 9q34; previously known as CAN). The exact mechanism by which the fusion protein DEK-NUP214 contributes to leukemia development has not been identified. Patients with t(6;9) AML have a very poor prognosis. The DEK/NUP214 t(6;9) specific FISH probe has been optimized to detect the reciprocal translocation t(6;9) in a dual-color, dual-fusion assay on metaphase/interphase spreads, blood smears and bone marrow cells.

References:
Von Lindern et al, 1992, Mol. Cell. Biol.,12; 1687-1697.
Ageberg et al, 2008, Gen. Chrom. Canc., 47; 276-287.
Chi et al, 2008, Arch. Pathol. Lab. Med., 132; 1835-1837.

Products

Products

KBI-10306
ON DEK / NUP214 t(6;9) Fusion
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Hematopathology
In Vitro Diagnostic Use
10 test
Dual Color > Red, Green
Cells
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent

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