In normal tissues, cytokeratins 8 and 18 are reported to be expressed in all simple and glandular epithelium and in neoplastic tissues, they have been reported to be expressed in adenocarcinomas and most squamous cell carcinomas. These cytokeratins are absent from keratinizing squamous carcinomas.
Product Specific Information
Clone 5D3 reacts with human cytokeratin intermediate filament proteins of 52.5 kD and 45 kD, identified as cytokeratins 8 and 18, respectively. Clone 5D3 shares similar specificities to clone CAM5.2 (Angus B et al. Journal of Pathology. 153: 377-384 (1987)).
Cytokeratin (8/18) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.