Human colon: immunohistochemical staining for Cytokeratin 20. Note the intense staining of surface mucosa. Cytokeratin 20: clone Ks20.8

Cytokeratin 20

cytokeratin-20

Antigen Background

Cytokeratin 20 has been demonstrated to be almost entirely confined to the gastric and intestinal epithelium, urothelium and Merkel cells of the skin. Cytokeratin 20 is less acidic than other type I cytokeratins and is of interest due to its restricted tissue expression. In normal tissue, cytokeratin 20 is expressed in intestinal epithelium, gastric foveolar epithelium, a number of endocrine cells in the upper portions of the pyloric glands, urothelium and Merkel cells in epidermis. In tumors it is reported, there is a marked difference in the expression of cytokeratin 20 within different carcinomas. Neoplasms expressing cytokeratin 20 are derived from normal epithelia which themselves expressed cytokeratin 20. Colorectal carcinomas consistently express cytokeratin 20, while gastric adenocarcinomas express cytokeratin 20 to a lesser degree. Adenocarcinomas of the gall bladder and bile duct, ductal cell adenocarcinomas of the pancreas, mucinous ovarian tumors, Merkel cell tumors and transitional cell carcinomas have also been reported to express cytokeratin 20.

Disclaimer

Cytokeratin 20 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • CK20-L-H
    0.5ml NCL-L-CK20
    KS20.8
    Liquid Concentrate
    P (HIER)
  • CK20-L-CE-H
    0.5ml NCL-L-CK20
    KS20.8
    Liquid Concentrate
    P (HIER)
  • This item replaces CK20-CE-SCK20-543-CE-SCK20-CECK20-543-SCK20-R-7-CECK20-L-CE-SCK20-L-SCK20-R-7
    CK20-L-CE
    1ml NCL-L-CK20
    KS20.8
    Liquid Concentrate
    P (HIER)
  • This item replaces CK20-543
    CK20-L
    1ml NCL-L-CK20
    KS20.8
    Liquid Concentrate
    P (HIER)
  • This item replaces CK20-561-L-CE-S
    CK20-561-L-CE
    1ml NCL-L-CK20-561
    PW31
    Liquid Concentrate
    P (HIER)
  • PA0037
    30ml Cytokeratin 20 Bond RTU Primary
    KS20.8
    BOND RTU
    P (HIER)
  • PA0022
    7ml Cytokeratin 20 Bond RTU Primary
    KS20.8
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

CK20-L-H
Tumor Differentiation
KS20.8
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
Research Use Only
1ml
CK20-L-CE-H
Tumor Differentiation
KS20.8
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
CK20-L-CE
Tumor Differentiation
KS20.8
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
CK20-L
Tumor Differentiation
KS20.8
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
Research Use Only
1ml
CK20-561-L-CE
Tumor Differentiation
PW31
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0037
Tumor Differentiation
KS20.8
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
30ml
PA0022
Tumor Differentiation
KS20.8
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

CK20-L-H
CK20-L-CE-H
CK20-L-CE
CK20-L
CK20-561-L-CE
PA0037
PA0022

Resources

Resources

Antigen Background

Cytokeratin 20 has been demonstrated to be almost entirely confined to the gastric and intestinal epithelium, urothelium and Merkel cells of the skin. Cytokeratin 20 is less acidic than other type I cytokeratins and is of interest due to its restricted tissue expression. In normal tissue, cytokeratin 20 is expressed in intestinal epithelium, gastric foveolar epithelium, a number of endocrine cells in the upper portions of the pyloric glands, urothelium and Merkel cells in epidermis. In tumors it is reported, there is a marked difference in the expression of cytokeratin 20 within different carcinomas. Neoplasms expressing cytokeratin 20 are derived from normal epithelia which themselves expressed cytokeratin 20. Colorectal carcinomas consistently express cytokeratin 20, while gastric adenocarcinomas express cytokeratin 20 to a lesser degree. Adenocarcinomas of the gall bladder and bile duct, ductal cell adenocarcinomas of the pancreas, mucinous ovarian tumors, Merkel cell tumors and transitional cell carcinomas have also been reported to express cytokeratin 20.

Disclaimer

Cytokeratin 20 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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