Pax-5

Antigen Background

Pax genes are a family of developmental control genes that encode nuclear transcription factors and have been implicated in the control of mammalian development. Pax-5 is a B cell specific transcription factor that is expressed in pro B cells, pre-B and mature B cells, and subsequently in all stages of B cell development until the plasma cell stage in which it is downregulated.

Disclaimer

Pax-5 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.