Colorectal carcinoma: immunohistochemical staining for mismatch repair protein (MSH2). Note nuclear staining in a high proportion of the malignant cells. Mismatch Repair Protein (MSH2): clone 79H11.

Mismatch Repair Protein (MSH2)

Antigen Background

Human mismatch repair protein 2 (MSH2) is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Therefore, the loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis. MSH2 is reported to be expressed in the nuclei of cells from a variety of tissues including thyroid, heart, smooth muscle and the germinal centers of lymphoid follicles. In ileum and colon, MSH2 expression has been reported in the crypts, the cells which are undergoing rapid renewal. They are responsible for the continuous production of differentiated cells which migrate over 2 to 4 days before being sloughed into the lumen.

Disclaimer

Mismatch Repair Protein (MSH2) is a recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Productos

Productos

MSH2-612-L-CE
1ml NCL-L-MSH2-612
o SOLICITE una cotización masiva.
PA0989
7ml MSH2 (79H11) Bond RTU Primary
o SOLICITE una cotización masiva.

Downloads

Downloads

MSH2-612-L-CE

PA0989

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