SS18 (18q11) Break probe hybridized to patient material showing translocation of the SYT (SS18) gene region at 18q11 (1RG1R1G).

IVD SS18 Break

The characteristic chromosomal abnormality in Synovial Sarcoma t(X;18)(p11.2;q11.2) is present in 90% of the patients. This translocation results in the fusion of the synovial sarcoma translocation, chromosome 18 (SS18) gene to either of two distinct genes, SSX1 or SSX2, located on the X chromosome. The SS18 (18q11) Break probe is optimized to detect translocations involving the SS18 gene region at 18q11 in a dual-color, split assay on paraffin embedded tissue sections.

Kawai et al, 1998, NEJM, 338; 153-160.
Surace et al, 2004, LabInvest., 84; 1185-1192.



SS18 (18q11) Break
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