20q- (20q12) / 20q11 probe hybridized to patient material showing 20q- deletion (1R2G). Material kindly provided by Labdia Labordiagnostik, Vienna.

IVD 20q-

Acquired deletions of the long arm of chromosome 20 are found in several hematologic conditions and particularly in the myeloproliferative disorders (MPD) and myelodysplastic syndromes and acute myeloid leukemia (MDS/AML). A minimal critical region deleted in MPD and MDS has been identified at 20q12 which includes a protein tyrosine phosphatase receptor gene. The 20q- (20q12) specific FISH probe is optimized to detect copy numbers of 20q at region 20q12. A 20q11 region specific probe is included to facilitate chromosome identification.

References:
Bench et al, 2000, Oncogene, 19; 3902-3913.
Asimakopoulos et al, 1994, Blood, 84; 3086-3094.

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KBI-10203
20q- (20q12) / 20q11
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