RUO - 1q21 / SRD

Frequent loss of heterozygosity (LOH) on the short arm of chromosome 1 (1p) has been reported in a series of human malignancies. The combination with the potentially amplified 1q21 region allows to detect deletions at 1p36 and gain of 1q21 in a single FISH assay. The 1q21 specific FISH probe is optimized to detect copy numbers at 1q21. The SRD 1p36 specific FISH probe is optimized to detect copy numbers of 1p at region 1p36 containing the markers D1S2795 and D1S253.

References:
Cremer et al, 2005, Genes Chrom Cancer, 44; 194-203.
Shaughnessy J., 2005, Hematology, 10 suppl, 1; 117-126.