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Antigen Background
Chromogranin Aは68kDの酸性タンパクで、神経組織および内分泌細胞(副甲状腺、副腎髄質、脳下垂体前葉、膵島細胞、甲状腺C細胞など)の分泌顆粒に発現することが報告されています。Chromogranin Aの発現は、下垂体腺腫、膵島細胞腫、褐色細胞腫、甲状腺髄様癌、メルケル細胞腫、カルチノイドなどの神経内分泌腫瘍で報告されています。
Disclaimer
Chromogranin A is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
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