Deletions affecting the long arm of chromosome 6 (6q) involving band 6q21 are among the most commonly observed chromosomal aberrations in lymphoid malignancies and have been identified as adverse prognostic factor in subsets of tumors. Amplification of MYC (8q24) has been described in many types of solid tumors, such as breast, cervical and colon cancers, as well as in myeloma, non-Hodgkin's lymphoma, gastric adenocarcinomas and ovarian cancer. The 6q21 / MYC (8q24) FISH probe is designed as a dual-color assay to detect deletions and amplifications at 6q21 and 8q24.
References: Zhang, Y, 2000, Genes, Chrom. And Canc. 27; 52-58. Bentz, M et al, 1995, Blood, 85; 3610-3618.
