RUO - 1q21 / SRD (1p36)

Frequent loss of heterozygosity (LOH) on the short arm of chromosome 1 (1p) has been reported in a series of human malignancies. The combination with the potentially amplified 1q21 region allows to detect deletions at 1p36 and gain of 1q21 in a single FISH assay. The 1q21-specific FISH probe is optimized to detect copy numbers at 1q21. The SRD 1p36-specific FISH probe is optimized to detect copy numbers of 1p at region 1p36 containing the markers D1S2795 and D1S253.

References:
Cremer et al, 2005, Genes Chrom Cancer, 44; 194-203.
Shaughnessy J., 2005, Hematology, 10 suppl, 1; 117-126.