Advancing Cancer Diagnostics, Improving Lives
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Hintergrund des Antigens
Der Gehalt an Estrogenrezeptor (ER) im Brustkrebsgewebe ist ein wichtiger Parameter für die Prognose des potenziellen Nutzens einer Hormontherapie. Die Einführung hochspezifischer monoklonaler Antikörper gegen ER hat es möglich gemacht, den Rezeptorstatus von Mammakarzinomen im Rahmen routinemäßiger histopathologischer Laboruntersuchungen zu bestimmen.
Klon 6F11 wurde auf die vollständige alpha-Form des auf dem humanen ER-Antigen vorhandenen Estrogenrezeptor-Moleküls, das sich im Zellkern ER-positiver normaler und neoplastischer Zellen befindet, abgestimmt. Klon 6F11 wurde umfassend getestet.
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