IVD ERBB2 (17q12) / SE 17

The proto-oncogene ERBB2 (HER-2 / neu) resides on chromosome 17q and encodes a transmembrane tyrosine kinase growth factor receptor Amplification of the ERBB2 gene, or overexpression of the ERBB2 protein, is found in 20- 30 % of breast cancers and is also found to be amplified in prostate carcinoma, gastric cancer and uterus cancer ERBB2 has been shown to predict response to specific breast cancer chemotherapeutic regimens, especially when combined with the humanized monoclonal antibody (Mab) Herceptin.

The ERBB2 (17q12) specific FISH probe is optimized to detect copy numbers of the ERBB2 (Her2/Neu) gene region at region 17q12. The Satellite Enumeration (SE) 17 FISH probe is included to facilitate chromosome identification.

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