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Polo样激酶-1 产品照片 Front View S
Squamous cell carcinoma of oropharangeal tissue: immunohistochemical staining of PLK-1. Note the intense nuclear and cytoplasmic staining of a proportion of proliferating malignant cells. Polo-Like Kinase-1: clone MJS1

Polo样激酶-1

plk-1
Polo样激酶-1（PLK1，也称为丝氨酸/苏氨酸蛋白激酶13）是一种66kDa激酶。PLK-1的活性对于有丝分裂是至关重要的，维持基因组的稳定性。PLK-1位于中心体和着丝粒，其在晚期和前中期发挥关键作用。PLK-1在许多类型的癌症中过表达，并介导乳腺癌细胞中雌激素受体介导的基因转录。PLK-1的过度表达与肿瘤发展有关，在非小细胞肺癌，头颈部，胃癌，乳腺癌，卵巢癌，结肠癌和其他几种癌症类型中报道的表达水平升高。

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PLK-1-L-CE
1ml NCL-L-PLK-1
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Polo样激酶-1