PD-L1

pd-l1
Antigen Background

Programmed death-ligand 1 (PD-L1), CD274 or B7 Homolog 1(B7-H1) is a protein encoded by the CD274 gene. When bound to its ligands, PD-1 and B7.1, it plays an immunosuppressive role by inhibiting T-cell activity. Overexpression of PD-L1 by cancer cells may enable them to evade the host immune response, conferring a growth advantage to such tumours. PD-L1 expression levels detected by immunohistochemistry can therefore be of prognostic value in some types of cancer.

PD-L1 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using nonimmunologic histochemical stains.


  • PA0832
    7mL PD-L1 (73-10) Bond RTU Primary
    73-10
    SDS(pdf)

Product Specifications

Product Specifications

PA0832
73-10
In Vitro Diagnostic Use

Documents

Documents

PA0832
SDS(pdf)

Resources

Resources

Antigen Background

Programmed death-ligand 1 (PD-L1), CD274 or B7 Homolog 1(B7-H1) is a protein encoded by the CD274 gene. When bound to its ligands, PD-1 and B7.1, it plays an immunosuppressive role by inhibiting T-cell activity. Overexpression of PD-L1 by cancer cells may enable them to evade the host immune response, conferring a growth advantage to such tumours. PD-L1 expression levels detected by immunohistochemistry can therefore be of prognostic value in some types of cancer.

PD-L1 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using nonimmunologic histochemical stains.


Recently Viewed

View All