Human placenta: immunohistochemical staining for Epidermal Growth Factor Receptor. High expression of EGFR localized in the trophoblastic layer of the placental villi. Epidermal Growth Factor Receptor: clone EGFR.113

Epidermal Growth Factor Receptor

epidermal-growth-factor-receptor
Antigen Background
Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kD with tyrosine kinase activity. Increased levels of EGFR are reported to be linked with malignant transformation of squamous cells eg in squamous cell carcinoma of the lung, head, neck, skin, cervix and esophagus. EGFR may also play a role in the development and progression of hepatocellular carcinomas where recurrence rates are higher in EGFR-positive cases. This correlation has similarly been reported in colorectal cancers where EGFR, produced by tumor cells, plays an important role in the invasiveness and proliferation of colorectal cancers. The majority of published studies of EGFR expression in human breast cancer has similarly shown an association with EGFR expression where it is inversely related to estrogen receptor status.

Product Specific Information
Clone EGFR.113 is raised to the extracellular domain of the EGFR molecule.

Disclaimer
Epidermal Growth Factor Receptor is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
  • This item replaces EGFREGFR-384-CEEGFR-384-R-7EGFR-384-SEGFR-384-CE-SEGFR-384-L-CEEGFR-LEGFR-384EGFR-384-LEGFR-CEEGFR-CE-S
    EGFR-L-CE
    1ml NCL-L-EGFR
    EGFR.113
    Liquid Concentrate
    P (HIER)
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Product Specifications

Product Specifications

EGFR-L-CE
Lung Pathology
EGFR.113
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml

Documents

Documents

EGFR-L-CE

Resources

Resources

Antigen Background
Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kD with tyrosine kinase activity. Increased levels of EGFR are reported to be linked with malignant transformation of squamous cells eg in squamous cell carcinoma of the lung, head, neck, skin, cervix and esophagus. EGFR may also play a role in the development and progression of hepatocellular carcinomas where recurrence rates are higher in EGFR-positive cases. This correlation has similarly been reported in colorectal cancers where EGFR, produced by tumor cells, plays an important role in the invasiveness and proliferation of colorectal cancers. The majority of published studies of EGFR expression in human breast cancer has similarly shown an association with EGFR expression where it is inversely related to estrogen receptor status.

Product Specific Information
Clone EGFR.113 is raised to the extracellular domain of the EGFR molecule.

Disclaimer
Epidermal Growth Factor Receptor is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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