CRLF2

crlf2

Rearrangement of the CRLF2 (Xp22/Yp11) gene is associated with poor outcome in pediatric B-progenitor and Down syndrome-associated acute lymphoblastic leukemia (ALL).

CRLF2-IGH fusions between Xp22-14q32 or Yp11-14q32 results in a deregulated expression of the cytokine receptor gene (CRLF2). This can also be the result of the fusion with the P2RY8 promoter on Xp22 or Yp11.

Gain of chromosome X has been observed in Down syndrome-associated ALL.

Literature:
Mullighan et al., 2009, Nat. Genet. 41(11): 1243-1246
Russell et al., 2009, Blood, 114(13): 2688-2698

  • 23P003C495
    CRLF2 (Xp22/Yp11) Distal Green 33µl 3x
  • 23P002C550
    CRLF2 (Xp22/Yp11) Proximal Red 33µl 3x
  • 23P004C550
    CRLF2 (Xp22/Yp11) Red 33µl 3x

Product Specifications

Product Specifications

23P003C495
Analyte Specific Reagent
Analyte Specific Reagent
33 µL
Single Color > Green
Gene Region-Specific
Fluorescent
3x
Manual Reagent
23P002C550
Analyte Specific Reagent
Analyte Specific Reagent
33 µL
Single Color > Red
Gene Region-Specific
Fluorescent
3x
Manual Reagent
23P004C550
Analyte Specific Reagent
Analyte Specific Reagent
33 µL
Single Color > Red
Gene Region-Specific
Fluorescent
3x
Manual Reagent

Documents

Documents

23P003C495
23P002C550
23P004C550

Resources

Resources

Rearrangement of the CRLF2 (Xp22/Yp11) gene is associated with poor outcome in pediatric B-progenitor and Down syndrome-associated acute lymphoblastic leukemia (ALL).

CRLF2-IGH fusions between Xp22-14q32 or Yp11-14q32 results in a deregulated expression of the cytokine receptor gene (CRLF2). This can also be the result of the fusion with the P2RY8 promoter on Xp22 or Yp11.

Gain of chromosome X has been observed in Down syndrome-associated ALL.

Literature:
Mullighan et al., 2009, Nat. Genet. 41(11): 1243-1246
Russell et al., 2009, Blood, 114(13): 2688-2698

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