ZNF217 (20q13) / 20q11 probe hybridized to tissue (2R2G).

RUO - ZNF217 / 20q11

ruo-znf217-20q11

Zinc-finger protein 217 (ZNF217) is a Kruppel-like zinc-finger protein located at 20q13.2, within a region of recurrent maximal amplification in a variety of tumor types, and especially breast cancer cell lines and primary breast tumors. Copy number gains at 20q13 are also found in more than 25% of cancers of the ovary, colon, head and neck, brain, and pancreas. ZNF217 is considered a strong candidate oncogene that may have profound effects on cancer progression, which is transcribed in multiple normal tissues, and overexpressed in almost all cell lines and tumors in which it is amplified. The ZNF217 (20q13) FISH probe is optimized to detect copy numbers of 20q at 20q13. The 20q11 probe is included to facilitate chromosome identification.

References:

Tanner M et al, 2000, Clin Cancer Res, 6; 1833-1839.

Ginestier C et al, 2006, Clin Cancer Res, 12; 4533-4544.

  • KI-10733
    ZNF217 (20q13) / 20q11
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Product Specifications

Product Specifications

KI-10733
Research
Research Use Only
10 test
Dual Color > Red, Green
Tissue
Amplification
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent

Documents

Documents

KI-10733

Resources

Resources

Zinc-finger protein 217 (ZNF217) is a Kruppel-like zinc-finger protein located at 20q13.2, within a region of recurrent maximal amplification in a variety of tumor types, and especially breast cancer cell lines and primary breast tumors. Copy number gains at 20q13 are also found in more than 25% of cancers of the ovary, colon, head and neck, brain, and pancreas. ZNF217 is considered a strong candidate oncogene that may have profound effects on cancer progression, which is transcribed in multiple normal tissues, and overexpressed in almost all cell lines and tumors in which it is amplified. The ZNF217 (20q13) FISH probe is optimized to detect copy numbers of 20q at 20q13. The 20q11 probe is included to facilitate chromosome identification.

References:

Tanner M et al, 2000, Clin Cancer Res, 6; 1833-1839.

Ginestier C et al, 2006, Clin Cancer Res, 12; 4533-4544.

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