RUO - WHSC1 / SE 4
Wolf-Hirschhorn Syndrome (WHS) affected individuals have prenatal-onset growth deficiency followed by postnatal growth retardation and hypotonia with muscle under-development. Developmental delay/mental retardation of variable degree is present in all. FISH analysis using a WHSC1 specific FISH probe for chromosomal locus 4p16.3 detects more than 95% of deletions in WHS. The Wolf-Hirschhorn region probe is optimized to detect copy numbers of the Wolf-Hirschhorn critical region at 4p16. The chromosome 4 Satellite Enumeration (SE 4) FISH probe at D4Z1 is included to facilitate chromosome identification.
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