Squamous cell carcinoma of oropharangeal tissue: immunohistochemical staining of PLK-1. Note the intense nuclear and cytoplasmic staining of a proportion of proliferating malignant cells. Polo-Like Kinase-1: clone MJS1

Polo-Like Kinase 1 (PLK-1)


Antigen Background

Polo-Like Kinase-1 (PLK1) also known as Serine/Threonine Protein Kinase 13 is a 66 kDa kinase. The activity of PLK-1 is crucial for mitosis and maintenance of genome stability. PLK-1 localizes to centrosomes and kinetochores where it plays a key role in late prophase and prometaphase. PLK-1 is overexpressed in many types of cancers and mediates estrogen receptor-mediated gene transcription in breast cancer cells. Overexpression of PLK-1 is associated with tumor development, with elevated levels of expression reported in non-small cell lung cancers, head and neck, gastric, breast, ovarian, colon and several other cancer types.


Polo-Like Kinase 1 (PLK-1) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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