RUO - TP53 / MPO
Isochromosome 17q is the most common isochromosome in cancer. It plays an important role in tumor development and progression. Hematologic malignancies such as chronic myeloid leukemia (CML) with isochromosome 17q carry a poor prognosis. Isochromosome 17q is the most common chromosome abnormality in primitive neuroectodermal tumors and medulloblastoma. Isochromosome 17q is, by convention, symbolized as i(17q). The TP53 (17p13) / MPO (17q22) "ISO 17q" FISH probe is optimized to detect copy numbers of the TP53 gene region at 17p13 and MPO gene region at 17q22. In case of i(17q) a signal pattern of three red signals for MPO (17q22) and one signal for TP53 at 17p13 is expected.
Becher et al, 1990, Blood, 75; 1679-1683.
Fioretos et al, 1999, Blood, 94; 225-232.