Antigen Background p40 (Delta Np63) is a truncated product of the p63. It is normally expressed in the basal or progenitor cell layer of stratified epithelia, basal cells of prostate, as well as myoepithelial cells of breast and salivary glands, and cytotrophoblasts in placenta, and shows a nuclear staining pattern with IHC. Among the numerous neoplasms positive for p40, squamous cell carcinomas of pulmonary and non-pulmonary origin can be identified from other malignancies.
Disclaimer p40 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
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