Colorectal carcinoma: immunohistochemical staining for mismatch repair protein (PMS2). Note nuclear staining in a high proportion of the malignant cells. Mismatch Repair Protein (PMS2): clone EP51.

错配修复蛋白(PMS2)

mismatch-repair-protein-pms2
减数分裂后分离增加2 (PMS2),又称PMS1蛋白同源物2,是一种DNA错配修复(MMR)蛋白。PMS2基因家族成员位于7号染色体上成簇出现。PMS2是一种与细菌突变基因同源的MLH1、MLH3和PMS1密切相关的96 kDa的错配修复蛋白。PMS2蛋白与MLH1蛋白形成异二聚体,在ATP存在下被激活; 这种复合物协调其他蛋白质的结合,修复细胞分裂准备过程中产生的DNA错误。肿瘤中PMS2表达的缺失有助于识别hMLH1突变载体,并确定其是否适合突变分析。PMS2基因缺陷在结直肠癌和微卫星不稳定性肿瘤中所占比的例虽小,但却很重要。

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PMS2-L-CE
1ml NCL-L-PMS2
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This item replaces PMS2-L-CE-S
M0R4G
Gastrointestinal Pathology
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0991
7ml PMS2 (EP51) Bond RTU Primary
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EP51
Gastrointestinal Pathology
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

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PMS2-L-CE

PA0991

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